Proinflammatory Cytokines Activate the Intrinsic Apoptotic Pathway in -Cells
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چکیده
منابع مشابه
Proinflammatory Cytokines Activate the Intrinsic Apoptotic Pathway in β-Cells
OBJECTIVE Proinflammatory cytokines are cytotoxic to beta-cells and have been implicated in the pathogenesis of type 1 diabetes and islet graft failure. The importance of the intrinsic mitochondrial apoptotic pathway in cytokine-induced beta-cell death is unclear. Here, cytokine activation of the intrinsic apoptotic pathway and the role of the two proapoptotic Bcl-2 proteins, Bad and Bax, were ...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2009
ISSN: 0012-1797,1939-327X
DOI: 10.2337/db08-0178